Type 2 Diabetes – Long-Term Sugar Control and Diabetic Retinopathy!

FILED IN Type 2 Diabetes No Comments

A technique known as “measuring lens fluorescence” is a useful way of assessing life-long blood sugar levels. The lens lasts a lifetime and it’s ageing process is affected by blood sugar. By measuring lens fluorescence, scientists can see how much ageing the blood sugar levels have caused, allowing them to estimate the amount of sugar that has been in the body over time.

Researchers in the Department of Ophthalmology, Glostrup Hospital, University of Copenhagen in Denmark carried out lens fluorescence imaging to discover whether the life-long level of blood sugar could be associated with the risk of diabetic retinopathy. Diabetic retinopathy is an important cause of blindness in diabetics, both Type 1 and Type 2. The blood vessels at the back of the eye are then affected and bleed into the eye. Results of the study on lens fluorescence were published in the journal Diabetologia in December 2010.
Mexican online pharmacy
Nine hundred volunteers between the ages of 30 and 60 were admitted to the study. One hundred and seventy were found to be diabetic and 35 already had a diagnosis of Type 2 diabetes. Retinopathy was diagnosed in 46 people, or 22 per cent of 205 volunteers with Type 2 diabetes. Those with twice the amount of lens fluorescence as the volunteers with lower amounts of fluorescence, had more than five times the risk of diabetic retinopathy. Smoking, blood pressure, height and weight proportions, and HbA1c were also found to be associated with retinopathy. It was also concluded retinopathy is associated with the amount of sugar in the blood in both Type 2 diabetes and pre-diabetes, and that life-long control of blood sugar could help to prevent diabetic retinopathy.

How will you keep your blood sugar levels down?

  • one way of satisfying a sweet tooth is to drink hot or iced tea with sucralose or stevia
  • some people like to sweeten seltzer water with non-sugar sweeteners and add some fruit juice for flavor
  • fruits are another good way of getting something sweet with less sugar and more fiber than you would get with high-sugar snacks made with highly refined flour and sugar
  • many people are reportedly including their dogs in their getting-fit resolutions for 2011, taking them for walks and playing with them. Even brushing your dog several times a week for fifteen minutes, changing hands halfway through will work your arms and please your dog

Why not check out the local gyms… many of them are competing with lower fees so shop around for the bargains. Some gyms offer discounts if you bring a friend along, and the added benefit of bringing a friend is that you can encourage each other. A membership to a local fitness center is a great way to get exercise in a safe and social environment.

Keeping your blood sugar levels in the range as discussed with your doctor, will help to prevent all diabetic complications.

, ,


Decreasing the Risk of Diabetic Retinopathy in a Type 2 Diabetes Study: Part 4

FILED IN Type 2 Diabetes No Comments

Mexican pharmacy

Case management may also have played a role in attendance at sessions when the photographs were taken and the immediate feedback that nonmydriatic photography can give to the health care team and thus facilitate the follow-up of patients with documented retinopathy. Whether it is the support associated with case management and the resultant adherence to nonglycemic targets such as hypertension that led to the improved retinal status, independent of improved glycemic control, cannot be addressed by this study. However, perhaps because case management clearly improves glucose control in a Medi-Cal–type population and is associated with decreased risk of new-onset retinopathy, comprehensive case management may be justified in similar health care settings.

Limitations of this study include the fact that it was not of sufficient duration to address whether case management may have also prevented progression of previously recognized retinopathy, which may have required more time or larger numbers to see an effect. Another limitation is the fact that we only used a single field for evaluation of the retina rather than the seven fields used in other studies of retinopathy, although in previous reports, this technique for diabetic retinopathy screening has been shown to be effective. In this way, minimal retinopathy may have been missed in the periphery at baseline and at the follow-up study. However, since both baseline and follow-up retinal fields were identical, it is most likely that our findings reflect a clinically meaningful decrease in the development of retinopathy over the 2-year time span that was tested. Furthermore, seven-field photography was not practical in this case management setting. Although all participants were urged to visit an ophthalmologist, those subjects with evidence of any retinopathy on the photograph were personally followed by the case management team to facilitate the consultation.

Although other studies show that improved glycemic control decreases the risk of retinopathy, this study is the first to show that even a relatively short duration of improved control (?2 years) instituted before the onset of clinically identifiable retinopathy can decrease the risk of developing new retinopathy. This study also underscores the risk of retinal disease in type 2 diabetes in that progression of retinopathy occurred within a relatively short time when glycemic control was not achieved. Further studies are necessary to determine whether early intervention to achieve glycemic control in established diabetes has a greater effect to reduce diabetic retinopathy than its introduction at a later stage of the disease.

, ,


Decreasing the Risk of Diabetic Retinopathy in a Type 2 Diabetes Study: Part 3

FILED IN Type 2 Diabetes No Comments

This report is the first evidence that intensive case management reduces risk of new-onset retinopathy in people with established type 2 diabetes. The U.K. Prospective Diabetes Study first demonstrated the effects of improved glycemic control on retinopathy in type 2 diabetes, but the subjects who participated in that landmark study were all newly diagnosed, whereas the patients without retinopathy in this study had a mean duration of diabetes of 7.5 years by the time the case management intervention was begun. Although the number of subjects with established retinopathy in this study was not sufficient to draw conclusions about progression of retinopathy compared with those who had none at baseline, the response observed in the latter suggests that early intervention with case management is an effective approach to reducing the burden of retinopathy in patients with type 2 diabetes. This conclusion is reinforced by the finding that even when case management is maintained for a short duration (mean <2 years), it is sufficient to diminish the risk of retinopathy.

The mechanisms for the effect of case management on reduction in the development of new-onset retinopathy may be related to any of the different facets of the case management process, although the major factor is likely to be improved glycemic control. Although A1C concentrations were not consistently evaluated at the time the follow-up photographs were taken, in the main trial the case management group showed a persistent improvement in the A1C that was greater than in the standard care group (6), suggesting that the decreased risk of retinopathy is likely due to improvement in glycemia. This study, therefore, confirms the necessity of providing adequate education and follow-up support, as delivered in this trial that utilized case management and frequent intervention, in order to achieve and maintain an A1C improvement over and above the standard care given to this county clinic Medi-Cal population.

However, other elements of the case management approach may well have contributed to the reduction in development of new-onset retinopathy. With adequate surveillance and support, glycemia improves, but, as demonstrated in our primary report, this improvement was associated with significant decreases from baseline to end of study in diastolic blood pressure, LDL cholesterol, and total cholesterol and an increase in HDL cholesterol in the intervention group. Thus, case management not only resulted in improvement of glycemic control but also had an effect on diminishing the risk of microvascular disease, as measured by retinopathy.

, ,


Decreasing the Risk of Diabetic Retinopathy in a Type 2 Diabetes Study: Part 2

FILED IN Type 2 Diabetes No Comments

One photograph was taken of each eye with a Canon CR4-45° nonmydriatic camera. Photographs were taken in a dark room to facilitate dilatation of the pupils and improve the quality of the photographs. Additionally, at the Los Angeles site, pupils were dilated before taking the photos. The retinal field photographed was identical at both sites and consisted of the area nasal to the disc and temporal to the macula and the superior and inferior arcades. All photographs were labeled with only the patient’s identification number and were sent for reading in Santa Barbara. Polaroid prints from the Canon camera were examined and graded by an experienced endocrinologist (L.J.) who, before this study, had readings verified by an ophthalmologist until agreement was virtually 100%. An overall grading was assigned for each eye at each examination using the Wisconsin Epidemiologic Study of Diabetic Retinopathy II/III–modified diabetic retinopathy levels, which used a modification of the Airlie House Criteria. This scale has nine levels per eye, ranging from no retinopathy to total vitreous hemorrhage. The scale was used as follows: no retinopathy (grade 10), very-mild nonproliferative diabetic retinopathy (NPDR) (grade 20), mild NPDR (grade 35), moderate NPDR (grade 43), severe NPDR (grade 53), mild proliferative diabetic retinopathy (PDR) (grade 61), moderate PDR (grade 65), high-risk PDR (grade 71), and advanced PDR and/or fundus partially obscured by disease (grade 85). Photograph quality was deemed adequate for accurate assignment of retinopathy grade in all of the graded photographs included for analysis. The primary outcome measures are the development of retinopathy of any degree in subjects without retinopathy at baseline and the progression of retinopathy in subjects with nonproliferative retinopathy at baseline.

Statistical analyses were performed using SAS statistical software for Windows version 9.1 (SAS Institute, Cary, NC). Continuous data were compared between groups with an unpaired t test, and categorical data were compared with a ?2 test. Odds ratio (OR) for progression of retinopathy in each group was estimated using the PROC GENMOD procedure while accounting for duration of follow-up and controlling for confounders. A repeated statement was used to specify within-subject effect. The first-order Taylor expansion approximation was used to estimate the variance of difference in the ORs between the two groups. Logistic regression with the development of any degree of retinopathy as the binary outcome variable was used to control for covariates in the subset of subjects who had no retinopathy in the baseline photograph.

There were 200 subjects (56 male and 144 female subjects) from the two centers who were included in the retinal photographic studies. Subjects randomized to the intervention (n = 102) and control (n = 98) groups were of similar age and diabetes duration, had similar A1C concentrations, had similar follow-up periods during this study, and had similar drop-out rates.

The progression or development of retinopathy was noted in both the intervention and control group, and the difference in the ORs for progression between the two groups (?0.65) was not statistically significant (P = 0.226). Subjects without evidence of retinal disease at baseline were evaluated separately. As with the total sample, the intervention and control groups were similar, with the exception of follow-up time. However, among 82 subjects who remained in the study through at least a second photograph and could therefore be used to assess the development of retinopathy, the follow-up was similar in the intervention (22.0 months) and the control groups (24.6 months, P = 0.136, data not shown). Those in the intervention group who had no evidence of retinopathy at baseline (Airlie House score = 10 in each eye) were less likely to develop diabetic retinal changes during a mean of 23.1 months of follow-up (5/48) than were those in the control group (10/34, ?2 = 4.805, df = 1, P = 0.028). This difference remained significant in a logistic regression model that controlled for age at diagnosis, duration of diabetes at baseline, duration of follow-up, A1C, ethnicity, and sex (OR 5.35 [95% CI 1.14–2.12], P = 0.034). In a stepwise logistic model, only randomization group, baseline A1C concentration, and age were significant predictors of developing retinopathy (data not shown).



Decreasing the Risk of Diabetic Retinopathy in a Type 2 Diabetes Study: Part 1

FILED IN Type 2 Diabetes No Comments

Between 1 July 1995 and 30 June 1999, a randomized, controlled study of subjects aged ?18 years who had type 2 diabetes of at least 1-year duration was conducted in southern California. Detailed information about the methods used in this study was presented in an earlier publication and will be briefly summarized here. Subjects with type 2 diabetes, as defined by the American Diabetes Association, were recruited at clinical sites in Santa Barbara, Los Angeles, and San Diego counties, three California counties serving predominantly ethnic minority, low-income Medicaid (called Medi-Cal in California) populations. Although specific income data were not collected as part of this study, overall 93.9% of the Medi-Cal–eligible population is classified as medically indigent or needy or is eligible for public assistance. Two of these sites, in Santa Barbara and Los Angeles counties, had access to fundus cameras and participated in the retinal photograph component of the study, and the data provided in this manuscript are limited to those two sites. Signed, witnessed, informed consent was obtained from all prospective participants using forms approved by local institutional review boards.

As previously described, the main trial recruited participants with HbA1c (A1C) levels >7.5%. At the two participating sites, 121 subjects were randomized to the intervention group and 119 to the control group. Intensive diabetes case management was provided to the intervention group in addition to the standard care that was received by both groups from a primary physician not connected with the trial. In the intervention group, subjects were seen or contacted by the case management staff at varying intervals according to the need (at least monthly) to lower A1C. In the control group, blood for A1C determination was collected at 6-month intervals, and contact between study staff and participants was generally limited to that needed to assure collection of A1C samples or to obtain retinal photographs. All subjects, in both the intervention and control groups, were referred for retinal photographs at baseline and then at least yearly. Two hundred subjects (98 control and 102 intervention subjects) had at least one photograph and 149 (70 control and 79 intervention subjects) had least two sets of retinal photographs that could be analyzed in this study. For subjects with more than two sets of photographs, only the first and last were used in this analysis. Only the main study had sufficient power to see differences in metabolic variables. Thus, for this small ancillary study of retinopathy, which utilized only two of three original participating centers, follow-up analyses of A1C, blood pressure, and lipids were not planned. Photographs were obtained at a separate case management visit, and, after baseline, photographs were not necessarily scheduled to coincide with the laboratory tests or physical examinations.

The study staff at each site, consisting of registered nurses and registered dietitians working in close collaboration with an endocrinologist, provided diabetes case management to the intervention group only. Evidence-based practice guidelines and algorithms for oral medicines and insulin initiation and adjustment were used in a collaborative practice model with the primary care provider. Treatment goals and targets for therapy were uniform across sites, with flexibility to utilize individualized treatment algorithms and strategies at each site. Interactions between the participant and study staff occurred in person at the clinic site and via telephone between visits as needed. The need for ancillary medical evaluations and/or services such as ophthalmologic examinations was monitored, with subsequent follow-up to ensure receipt of services, results retrieval, and communication of results to the primary care provider.

, ,